DEC 2016

Published by ORTHOWORLD Inc., BONEZONE delivers strategic sourcing & product commercialization solutions to orthopaedic device company decision makers and their partners.

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3 BONEZONE • December 2016 , Volume 15 | Issue 5 | December 2016 Editorial & Production Chief Content Officer Carolyn LaWell: Editorial Assistant Julie Vetalice: Media Production Coordinator Karen Young: BONEZONE is printed 5 times per year in March, June, August, October and December by ORTHOWORLD. Online content is published monthly at www.B O N E Z O N E 8401 Chagrin Road, Suite 18 Chagrin Falls, Ohio 44023 USA www.O R T H O W O R L D .com Copyright © 2002-2016 by ORTHOWORLD Inc. All rights reserved. IN THE ZONE INDUSTRY ADVISORY BOARD A world-class board of industry advisors steers BONEZONE and OMTEC® toward relevant and timely educational content that is consistent with the needs of OEM professionals and companies. Acumed Loren Blanchard Vice President of Manufacturing, General Manager: Acute Innovations Arthrex Lance Provance Supply Chain Manager DePuy Synthes Sharon Starowicz Director, Regulatory Policy Innovation, Global Orthopaedics, Johnson & Johnson K2M Rich Woods Senior Vice President, Global Research, Development & Engineering MicroPort Orthopedics Scott Shankle Vice President, Quality, Interim Vice President of Manufacturing & Procurement Smith & Nephew Orthopaedics Mark Hall Global Commodity Leader – Implants, Advanced Surgical Devices Stryker Orthopaedics Kenneth Trimmer Chief Engineer - Knees Tyber Medical Jeff Tyber President, CEO and Founder Wright Medical Group Thierry Manceau Vice President, Global Manufacturing & General Manager Wright Medical Group Jeremy Townsend Senior Manager, Global Supply Chain Zimmer Biomet Michael Esch Director, Product Development, Knee Creations Zimmer Biomet Howard Levy Vice President, Global Sourcing Matthew Poggie Independent Industry Advisor December is always our time to reflect on the past 12 months in order to prepare for the year ahead. What did we do that contributed the most to success? Where did we underperform? What are our priorities for the New Year? Who—inter- nally and externally—has the expertise needed to accomplish those priorities? This issue of BONEZONE follows that same theme. As 2016 comes to an end, we look back at what fueled growth and shaped the industry. Throughout 2016, the pages of BONEZONE brought commentary on the need for companies to respond to hospital customers' calls to be more than hardware companies, but also service providers. We weren't surprised to see, then, that product and service launches drove growth. This year, the top five orthopaedic companies ranked by revenue (DePuy Synthes, Zimmer Biomet, Stryker, Smith & Nephew, Medtronic) announced programs to address the components of episodes of care, specifically for joint replacement. In our NASS 2016 recap (page 14) and review of product introductions (page 16), we note commonalities within each market segment. The trend of larger companies expanding portfolios through the purchase of smaller companies continued to change the makeup of industry players, as you'll read in our M&A recap (page 80). In the first 11 months of 2016, 46 strategic transactions were announced. Compared to the 36 transactions in all of 2015, it's fair to say M&A activity remained hot. In this issue, we also look to the years ahead and provide industry-leading voices on what future supply chains will entail (page 66), and how questions surround- ing quality and technical advancements will impact the adoption of additive manufacturing (page 74). As you consider what and who it will take to achieve your objectives—maybe supply chain or manufacturing enhancements—one year, two years or five years out, what outside perspectives do you seek? The December issue remains syn- onymous with the Supplier & Service Provider Directory (page 22). More than 250 companies are listed and ready to offer you support in contract manufac- turing, business development, financial resources, human relations, regulatory affairs and more. We offer up the suggestion that you think of the directory as a Partner Portal. A partner seeks to understand your past successes and shortcomings, and assists you in strategizing how to accomplish your priorities in the year(s) ahead. Close-up image of a 3D woven scaffold (fibers appear in red) seeded with stem cells (green). The cells infiltrate the pores between the fiber bundles and then form cartilage that has the overall hemispherical shape of the scaffold. Image courtesy of Cytex Therapeutics,

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